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KMID : 0605620060130040279
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Journal of Korean Society of Biological Psychiatry
2006 Volume.13 No. 4 p.279 ~ p.288
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Relationship between SNP A and P1763 Polymorphisms on Dystrovrevin Binding Protein 1(TNBP1) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenic Patients
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Lee Chang-Hee
Seo Han-Gil
Kim Bong-Jo
Hahn Kyu-Hee
Kim Ki-Hoon
Shin Tae-Min
Woo Sung-Il
Cho Sook-Hyun
Byun Ki-Ook
Park Byung-Rae
Shin Hyoung-Doo
Park Jin-Soo
Kim Lyoung-Hyo
Kim Dong-Hyeon
Kim Im-Yel
Lee In-Sang
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Abstract
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Objectives:We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients.
Methods:We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups.
Results:The Ln S/N ratio(mean+/-SD) of the good SPEM function group was 4.39+/-0.33 and the ratio of poor SPEM function group was 3.17+/-0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function.
Conclusions:The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.
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KEYWORD
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Schizophrenia, Dystrobrevin Binding Protein 1(DTNBP1), Smooth Pursuit Eye Movement(SPEM), Genetic polymorphism
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